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RA Capital Management

Multi-Strategy

RA Capital Management · Filed 2026-08-14 · CIK 0001346824 · Q2 2026

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Form ADV discretionary AUM, 2026-10-02i
$16.40B
13F Equity Value
$11.51B
As of Q2 2026
13F / AUM
70.2%
Positions
89
13F long book at a glance — % of AUM
ASND · 17%
PBLS
RYTM
PCVX
+79 more · 28%
NON-13F · 30%
Min weight:
#
Value
# SharesSourceWeight
1
ASCENDIS PHARMA A/SHIST
ASND
$2.74B
16.7%10,281,496+10,281,496NEW16.59%13F
2
PARABILIS MEDICINES INCHIST
PBLS
$0.79B
4.8%28,933,371+28,933,371NEW23.80%13F+13D
3
RHYTHM PHARMACEUTICALS INCHIST
RYTM
$0.74B
4.5%6,666,837——9.90%13F+13G
4
VAXCYTE INCHIST
PCVX
$0.67B
4.1%11,474,599——8.90%13F+13G
5
SIONNA THERAPEUTICS INCHIST
SION
$0.44B
2.7%9,905,045——14.30%13F+13D
6
TYRA BIOSCIENCES INCHIST
TYRA
$0.39B
2.4%12,198,625——19.90%13F+13D
7
EDGEWISE THERAPEUTICS INCHIST
EWTX
$0.34B
2.1%8,392,730(2,035,707)(19.5%)7.80%13F+13G
8
NEWAMSTERDAM PHARMA CO NVHIST
NAMS
$0.32B
2.0%9,550,191——7.99%13F
9
HEMAB THERAPEUTICS HOLDINGSHIST
COAG
$0.29B
1.7%7,808,627+7,808,627NEW16.72%13F
10
SEPTERNA INCHIST
SEPN
$0.23B
1.4%6,995,858——11.80%13F+13D
11
BICARA THERAPEUTICS INCHIST
BCAX
$0.22B
1.3%7,255,993——10.97%13F
12
MINERALYS THERAPEUTICS INCHIST
MLYS
$0.21B
1.3%7,692,750——8.70%13F
13
GH RESEARCH PLCHIST
GHRS
$0.21B
1.3%7,636,813(39,884)(0.5%)7.10%13F+13G
14
DISC MEDICINE INCHIST
IRON
$0.18B
1.1%2,450,221——5.90%13F+13G
15
SPYGLASS PHARMA INCHIST
SGP
$0.18B
1.1%8,021,117——23.98%13F
16
ARTIVA BIOTHERAPEUTICS INCHIST
ARTV
$0.17B
1.1%17,955,642+8,102,340+82.2%37.90%13F+13D
17
JANUX THERAPEUTICS INCHIST
JANX
$0.17B
1.0%11,189,693——18.30%13F
18
TAYSHA GENE THERAPIES INCHIST
TSHA
$0.16B
1.0%23,555,648——9.90%13F+13G
19
BIOCRYST PHARMACEUTICALS INCHIST
BCRX
$0.16B
1.0%15,827,186——6.20%13F+13G
20
WAVE LIFE SCIENCES LTDHIST
WVE
$0.16B
1.0%26,975,505——13.40%13F+13D
21
NUVALENT INC-AHIST
—
$0.15B
0.9%1,246,456(1,287,689)(50.8%)—13F
22
ABIVAX SA-ADRHIST
ABVX
$0.15B
0.9%1,132,557+1,132,557NEW1.44%13F
23
ORUKA THERAPEUTICS INCHIST
ORKA
$0.15B
0.9%1,554,597+1,554,597NEW2.35%13F
24
CLIMB BIO INCHIST
CLYM
$0.15B
0.9%11,300,939——33.00%13F+13D
25
SOLID BIOSCIENCES INCHIST
SLDB
$0.12B
0.7%12,036,126+2,696,148+28.9%11.90%13F+13D
26
ZAI LAB LTD-ADRHIST
ZLAB
$0.11B
0.7%5,743,533+36,271+0.6%6.48%13F
27
ARS PHARMACEUTICALS INCHIST
SPRY
$0.09B
0.5%10,860,977——10.92%13F
28
XENCOR INCHIST
XNCR
$0.08B
0.5%5,274,274+377,037+7.7%7.09%13F
29
JADE BIOSCIENCES INCHIST
JBIO
$0.08B
0.5%3,671,083——5.77%13F
30
INTELLIA THERAPEUTICS INCHIST
NTLA
$0.08B
0.5%4,526,926+4,526,926NEW3.23%13F
31
LB PHARMACEUTICALS INCHIST
LBRX
$0.07B
0.4%2,208,604——8.70%13F+13G
32
DEFINIUM THERAPEUTICS INCHIST
DFTX
$0.07B
0.4%1,500,000+1,500,000NEW1.12%13F
33
ACLARIS THERAPEUTICS INCHIST
ACRS
$0.07B
0.4%12,723,026+5,918,954+87.0%9.10%13F+13G
34
4D MOLECULAR THERAPEUTICS INHIST
FDMT
$0.07B
0.4%5,049,779——10.14%13F
35
SANA BIOTECHNOLOGY INCHIST
SANA
$0.07B
0.4%18,750,000+18,750,000NEW6.30%13F+13G
36
DAMORA THERAPEUTICS INCHIST
DMRA
$0.06B
0.4%2,399,702+392—3.89%13F
37
MONOPAR THERAPEUTICS INCHIST
MNPR
$0.06B
0.4%667,207——9.90%13F+13G
38
ACUMEN PHARMACEUTICALS INCHIST
ABOS
$0.06B
0.3%20,992,669——29.50%13F+13D
39
GERON CORPHIST
GERN
$0.05B
0.3%42,809,751(20,961,615)(32.9%)9.90%13F+13G
40
REZOLUTE INCHIST
RZLT
$0.05B
0.3%9,445,039+265,039+2.9%9.77%13F
41
EVOMMUNE INCHIST
EVMN
$0.05B
0.3%3,494,638——11.00%13F+13D
42
VOR BIOPHARMA INCHIST
VOR
$0.04B
0.3%2,402,095(3,002,903)(55.6%)19.90%13F+13D
43
CENTURY THERAPEUTICS INCHIST
IPSC
$0.04B
0.3%17,754,430——9.90%13F+13G
44
AKTIS ONCOLOGY INCHIST
AKTS
$0.04B
0.3%1,314,405(188,679)(12.6%)2.53%13F
45
BIOAGE LABS INCHIST
BIOA
$0.04B
0.2%1,671,648+21,000+1.3%3.64%13F
46
C4 THERAPEUTICS INCHIST
CCCC
$0.04B
0.2%8,000,000——9.90%13F+13G
47
MIRUM PHARMACEUTICALS INCHIST
MIRM
$0.04B
0.2%318,554——0.49%13F
48
CAPRICOR THERAPEUTICS INCHIST
CAPR
$0.04B
0.2%1,507,844——5.20%13F+13G
49
PEPGEN INCHIST
PEPG
$0.04B
0.2%20,064,545——28.97%13F
50
PRELUDE THERAPEUTICS INCHIST
PRLD
$0.03B
0.2%6,475,882+6,475,882NEW8.11%13F
51
NKARTA INCHIST
NKTX
$0.03B
0.2%10,805,129——15.09%13F
52
Q32 BIO INCHIST
QTTB
$0.03B
0.2%2,332,457+2,332,457NEW9.80%13F+13G
53
ANTERIS TECHNOLOGIES GLOBALHIST
AVR
$0.03B
0.2%3,000,000——3.08%13F
54
EDITAS MEDICINE INCHIST
EDIT
$0.03B
0.2%8,889,000+8,889,000NEW5.80%13F+13G
55
OVID THERAPEUTICS INCHIST
OVID
$0.03B
0.2%10,500,968(213,032)(2.0%)9.90%13F+13G
56
ASSEMBLY BIOSCIENCES INCHIST
ASMB
$0.03B
0.2%1,020,410——5.01%13F
57
ALX ONCOLOGY HOLDINGS INCHIST
ALXO
$0.03B
0.2%13,011,849——9.41%13F
58
BENITEC BIOPHARMA INCHIST
BNTC
$0.02B
0.2%1,850,000——5.30%13F
59
LENZ THERAPEUTICS INCHIST
LENZ
$0.02B
0.1%4,178,823——13.30%13F
60
LEXEO THERAPEUTICS INCHIST
LXEO
$0.02B
0.1%5,000,000——6.09%13F
61
ACRIVON THERAPEUTICS INCHIST
ACRV
$0.02B
0.1%12,229,396+3,888,888+46.6%28.54%13F
62
ALTIMMUNE INCHIST
ALT
$0.02B
0.1%6,500,000+6,500,000NEW3.34%13F
63
KARYOPHARM THERAPEUTICS INCHIST
KPTI
$0.02B
0.1%1,917,354——9.90%13F+13G
64
BRIGHT MINDS BIOSCIENCES INCHIST
DRUG
$0.02B
0.1%265,000——5.86%13F
65
AVALO THERAPEUTICS INCHIST
AVTX
$0.02B
0.1%1,000,000+337,032+50.8%6.30%13F+13G
66
ONKURE THERAPEUTICS INC-AHIST
OKUR
$0.02B
0.1%3,998,333——9.87%13F
67
FAETH THERAPEUTICS INCHIST
FTH
$0.02B
0.1%722,020+722,020NEW2.79%13F
68
AURA BIOSCIENCES INCHIST
AURA
$0.02B
0.1%2,500,000+2,500,000NEW2.41%13F
69
SAB BIOTHERAPEUTICS INCHIST
SABS
$0.02B
0.1%4,401,500——9.90%13F+13D
70
SEAPORT THERAPEUTICS INCHIST
SPTX
$0.02B
0.1%700,000+700,000NEW1.31%13F
71
PALISADE BIO INCHIST
PALI
$0.01B
0.1%7,124,116——9.90%13F+13G
72
HELIX ACQUISITION CORP-CL AHIST
HLXC
$0.01B
0.1%1,250,000———13F
73
WAYSTAR HOLDING CORPHIST
WAY
$0.01B
0.1%529,400——0.28%13F
74
EQUILLIUM INCHIST
EQ
$0.01B
0.1%3,096,336——9.90%13F+13G
75
MACROGENICS INCHIST
MGNX
$0.01B
0.1%1,864,176——2.93%13F
76
PERCEPTIVE CAPITAL SOLUTIONSHIST
FRNM
$0.01B
0.0%750,000———13F
77
ADICET BIO INCHIST
ACET
$0.01B
0.0%932,624(250,000)(21.1%)9.90%13F+13G
78
NEWAMSTERDAM PHARMA CO NV-27HIST
NAMSW
$0.01B
0.0%333,333——0.28%13F
79
CORVUS PHARMACEUTICALS INCHIST
CRVS
$0.01B
0.0%450,000——0.53%13F
80
RANI THERAPEUTICS HOLDINGS-AHIST
RANI
$0.01B
0.0%8,500,000——9.90%13F+13G
81
JATT II ACQUISITION CORPHIST
JATT
$0.01B
0.0%500,000+500,000NEW6.41%13F
82
AMANAT ACQUISITION CORP CL AHIST
AMAN
$0.00B
0.0%375,000+375,000NEW—13F
83
WEREWOLF THERAPEUTICS INCHIST
HOWL
$0.00B
0.0%2,387,744(4,293,563)(64.3%)4.10%13F+13D
84
PALATIN TECHNOLOGIES INCHIST
PTN
$0.00B
0.0%62,124(7,876)(11.3%)3.49%13F
85
Corbus Pharmaceuticals Holdings, Inc.Off-13F
CRBP——1,914,788——9.90%13G
86
BetterLife Pharma Inc.Off-13F
BETRF——55,420,000——9.00%13G
87
JATT III Acquisition CorpOff-13F
JTTT——450,000——5.10%13G
88
Latigo Biotherapeutics, Inc.Off-13F
LTGO——5,295,690——8.40%13G
89
CervoMed Inc.Off-13F
CRVO——1,266,143——8.60%13G
Positions are primarily from the latest 13F-HR. Rows marked Off-13F are >5% stakes disclosed in Schedule 13D/13G filings — they capture holdings (incl. recent or non-13F-eligible names) the quarterly 13F may omit; these report shares and percent of class but not dollar value, so value is shown only for 13F positions. Chg Shares is the absolute change vs the same position in the prior quarter's 13F. % Out is position shares ÷ issuer shares outstanding (from the issuer's latest XBRL cover-page figure; weighted-average basic shares as a fallback), or the percent of class reported on a 13D/13G. Where a figure can't be sourced from a filing it shows “—” — never an estimate.